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IMMUNE SUPPORT

Nitric oxide plays many important roles in the immune system. It is produced in high amounts from specialized cells of the immune system called macrophages.

DIGESTIVE SUPPORT

In the gastrointestinal tract, Nitric Oxide is involved in the regulation of regional blood flow, smooth muscle relaxation, secretory and immunological function. [1]

VASCULAR SUPPORT

Since it was identified as the elusive endothelium-derived relaxing factor in the 1980s, nitric oxide (NO) has rapidly gained status as one of the most important signalling molecules in the cardiovascular system. [1]

MOBILITY SUPPORT

Nitric oxide (NO) can modulate the release of various inflammatory mediators from a wide range of cells participating in inflammatory responses (e.g., leukocytes, macrophages, mast cells, endothelial cells, and
platelets).[1]

MEMORY SUPPORT

Nitric oxide (NO) is well established as a molecule necessary for memory processing across a wide variety of tasks and species, from odour discrimination in honey bees (Muller, 1996) to delayed recall in primates (Prendergast et al., 1997).[1]

REST SUPPORT

Nitric Oxide helps reduce anxiety and depression in part because it reduces inflammation and oxidative stress. It also restores circulation and supports healthy blood pressure, which is often elevated in people under stress and with chronic PTSD, thus becoming another risk factor for vascular dementia. [1]

Immune Support

In the immune system, nitric oxide is produced by macrophages, which are a type of leukocyte (white blood cell) that engulfs bacteria and other foreign particles that have invaded the body.[1] The nitric oxide released by macrophages may help reduce bacteria, parasites, and tumour cells by disrupting their metabolism.[1]

Nitric oxide (NO) is an intercellular messenger and has been recognized as one of the most versatile players in the immune system. Cells of the innate immune system: macrophages, neutrophils and natural-killer cells use pattern recognition receptors to recognize molecular patterns associated with pathogens. Activated macrophages then inhibit pathogen replication by releasing a variety of effector molecules, including NO.[2]

In addition to macrophages, a large number of other immune system cells produce and respond to NO. Thus, NO is important as a toxic defense molecule against infectious organisms. It also affects the functional activity, growth and death of many immune and inflammatory cell types including macrophages, T lymphocytes, antigen-presenting cells, mast cells, neutrophils and natural-killer cells.[2]

PDF Downloads:

  • The Effects of Nitric Oxide on the Immune Response During Giardiasis
  • Nitric Oxide: It’s Role in Immunity
  • The Role of Nitric Oxide in Immune Response Against Trypanosoma Cruzi Infection

References:

Immune Support

[1] Britannica, The Editors of Encyclopaedia. “nitric oxide”. Encyclopedia Britannica, 25 Aug. 2017, https://www.britannica.com/science/nitric-oxide. Accessed 18 January 2022.

[2] Nitric oxide and immune response.Tripathi P. Indian J Biochem Biophys. 2007 Oct;44(5):310-9.

PMID: 18341206 Review. https://pubmed.ncbi.nlm.nih.gov/18341206/

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